Gelatinous Transformation of the Bone Marrow: A Rare Presentation
نویسندگان
چکیده
Gelatinous bone marrow transformation (GMT) is a rare disorder of unknown pathogenesis. It is characterized by fat cell atrophy, focal loss of hematopoietic cells and deposition of extracellular gelatinous substances, which histochemically are mucopolysaccharides and rich in hyaluronic acid. GMT occurs more often in adults males than in females. The spectrum of underlying diseases is heterogeneous and age dependent. Anorexia nervosa, acute febrile states and AIDS in younger ages (<40 years), alcoholism and lymphomas in middle ages, and carcinomas, lymphomas, and chronic heart failure in older ages (>60 years) were most commonly associated with GMT. GMT may be reversible if the underlying disorder can be eliminated. In conclusion, GMT represents an indicator of severe illness in a patient but is not specific for a particular disease.
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